Platelet
derived wound healing factors in the treatment of thalassaemic leg ulcers
Leg ulcers can be encountered in patients suffering
from thalassaemia, and the reason for their occurrence is complex and multifactorial.
Such ulcers are very difficult to treat, take a long
time to heal, and many times, do not heal at all.
Platelet derived wound healing formula (PDWHF) is derived
from the alpha-granules of platelets and consists of 5 growth factors,
each of which produces a different cellular activity, that collectively
cause acceleration of epidermal tissue regeneration.
The aim of this study is to determine whether growth
factors derived from platelets can accelerate the healing of ulcers due
to thalassaemia.
Prior to study commencement, a wound specialist determined
whether the patient would need surgical debridement or not. Wound swabs
were also taken, in order to exclude the presence of infection.
Platelets were obtained from a pooled blood sample at
the blood transfusion centre, and processed further according to the protocol
for PDWHF extraction.
The patient applies the growth factor solution every
evening prior to retiring. The alternate day dressing consists of a saline-moistened
gauze.
The patient visits the Thalassaemia Clinic once a week
to have the ulcers medically assessed.